![Thyroid Hormone, the "Fire of Life" of the Human Body](/static/image/index/logo.png "Thyroid Hormone, the "Fire of Life" of the Human Body"){kind=logo}
The thyroid hormone produced by the thyroid gland, the "little butterfly of the human body", is often referred to as the "fire of life" of the human engine. However, the fire of life, whether it burns too strong, or the fire is weak, may not be able to maintain the normal function of the body, triggering the occurrence of thyroid disease, we will unveil the human body little butterfly and the "fire of life" between the story.
Thyroid Hormone Family
T3 and T4, are thyroid hormones.The T3 family is subdivided into TT3 and FT3, and the T4 family is subdivided into TT4 and FT4.
T3 and T4, are thyroid hormones.The T3 family is subdivided into TT3 and FT3, and the T4 family is subdivided into TT4 and FT4.
The main raw material for the synthesis of thyroid hormones is the iodine atom, TT3, FT3, TT4, and FT4, which are divided into two families based on the amount of iodine they possess.
The T4 Family
Has 4 iodine total thyroxine (TT4) and free thyroxine (FT4). FT4 is the physiologically active form of TT4 and is a true reflection of the functional state of the thyroid gland. T4 is the main product of thyroid secretion and an indispensable component of the hypothalamic-pituitary-thyroid regulatory system. T4 measurement can be used for the diagnosis of hyperthyroidism, the determination of primary and secondary hypothyroidism, and the monitoring of TSH suppression therapy.
The T3 Family
Has 3 iodine triiodothyronine (TT3) and free triiodothyronine (FT3). FT3 is the physiologically active form of TT3. FT3 is sensitive for the diagnosis of hyperthyroidism, is specific for the diagnosis of T3 hyperthyroidism, and is not affected by alterations in binding protein concentration or binding capacity. T3 is an important hormone in the action of thyroid hormones on various target organs, mainly outside the thyroid gland, most of which is produced in the liver from T4 via deiodination. Therefore, T3 concentration reflects the function of the thyroid gland on peripheral tissues better than it reflects the secretory status of the thyroid gland. T3 is an important indicator for identifying early hyperthyroidism and monitoring recurrent hyperthyroidism.
Role of Thyroid Hormones
The T4 Family
Has 4 iodine total thyroxine (TT4) and free thyroxine (FT4). FT4 is the physiologically active form of TT4 and is a true reflection of the functional state of the thyroid gland. T4 is the main product of thyroid secretion and an indispensable component of the hypothalamic-pituitary-thyroid regulatory system. T4 measurement can be used for the diagnosis of hyperthyroidism, the determination of primary and secondary hypothyroidism, and the monitoring of TSH suppression therapy.
The T3 Family
Has 3 iodine triiodothyronine (TT3) and free triiodothyronine (FT3). FT3 is the physiologically active form of TT3. FT3 is sensitive for the diagnosis of hyperthyroidism, is specific for the diagnosis of T3 hyperthyroidism, and is not affected by alterations in binding protein concentration or binding capacity. T3 is an important hormone in the action of thyroid hormones on various target organs, mainly outside the thyroid gland, most of which is produced in the liver from T4 via deiodination. Therefore, T3 concentration reflects the function of the thyroid gland on peripheral tissues better than it reflects the secretory status of the thyroid gland. T3 is an important indicator for identifying early hyperthyroidism and monitoring recurrent hyperthyroidism.
Role of Thyroid Hormones
- Promotes growth and development: thyroid hormones are essential for normal growth, development, and differentiation of the body, and are particularly important in the growth and development of the brain and bones.
- The thermogenesis effect of thyroid hormones is a manifestation of enhanced oxidative metabolism, which is realized through several pathways.
- Glucose metabolism: thyroid hormone can promote the utilization of sugar in peripheral tissues, and also promote the synthesis of glycogen, thus increasing the rate of glucose metabolism and lowering blood glucose. At the same time, thyroid hormone can promote the absorption of glucose in the gastrointestinal tract, hepatic gluconeogenesis, the breakdown of hepatic glycogen, and enhance the gluconeogenic effects of glucagon, glucagon, adrenaline, and growth hormone, and other glucose-enhancing hormones, to raise the level of blood glucose.
- Lipid metabolism: thyroid hormones promote all aspects of lipid metabolism and accelerate the rate of fat metabolism, including fat synthesis and catabolism, but promote synthesis more than catabolism. Blood cholesterol levels are often lower than normal in patients with hyperthyroidism, whereas patients with hypothyroidism have elevated blood cholesterol levels.
- Protein metabolism: under physiological conditions, thyroid hormones promote the transcription and translation processes of various proteins with an overall positive nitrogen balance. Thyroid hormones promote the synthesis of both structural and functional proteins and have a role in the regulation of growth development and functional activities of the organism. Thyroid hormones also promote protein degradation, causing a negative nitrogen balance.
- Nervous system: thyroid hormones increase central nervous system excitability while maintaining normal mental awareness. Patients with hyperthyroidism often experience symptoms such as irritability, irritability, hyperactivity, and insomnia.
- Cardiovascular system: thyroid hormone can increase the total amount of myofibrillar proteins and myosin, increase the expression of ATPase, and promote the release of Ca2+ from the sarcoplasmic reticulum of cardiomyocytes, exerting a positive forcing effect.
- Hematologic system: thyroid hormones increase renal erythropoietin secretion, which promotes erythropoiesis and increases 2,3-DPG levels in red blood cells. Thyroid hormone promotes the release of oxygen from oxygenated hemoglobin in erythrocytes, which facilitates the supply of oxygen to tissues.
- Respiratory system: thyroid hormones maintain the sensitivity of the respiratory center to hypoxic and hypercapnic stimuli.
- Urinary system: thyroid hormone can increase the glomerular filtration rate of the kidneys, increase urine output, and promote water excretion.
- Exercise system: thyroid hormone promotes bone growth and has a permissive effect on the growth-promoting effects of IGF-1; maintains GH secretion. Thyroid hormone promotes bone formation, bone growth, and bone turnover; increases bone resorption, elevates blood calcium, and promotes calcium excretion from urine.
- Endocrine and Reproductive System: allows for a wide range of hormones, increases the secretion of other hormones as well as the tissue requirements for them, and improves the metabolic rate of a wide range of hormones. Maintains normal libido and sexual function.
Hot Selling ELISA Kits
Jonlnbio Thyroid Hormone ELISA Kits, to help research work on the mechanism of research and exploration.